Tetrahidropiran Spiro pirrolidinonas piperidinonas replaced and Pharmaceutical compositions containing them, and Use thereof in the treatment and / or prevention of CNS diseases, such as Alzheimer's and Parkinson's, among others.

摘要

The compounds in this application are modulators of the H3 receptor and are therefore useful as pharmaceutical preparations, especially in the treatment and / or prevention of various diseases regulated by the H3 receptor, including those related to the central nervous system. Claim 1: a formula compound (1), wherein m is 1 or 2; n is 1 or 2; P is 1 or 2; R1 is hydrogen, C1-4 tar, CF3, c1-4-c1-4-tar, R2 is hydrogen, halogen, C1-4 tar or CF3; or salt or its enantiomer or enantiomer.