Method for preparing acid (+) - 1,4 - dihydro - 7 - (3S, 4S) - 3 - methoxy - 4 - (methylamino) - 1 - pirrolidinil - 4 - oxo - 1 - (2 - thiazolyl) - 1.8 - naftiridin - 3 - carboxylic acid

摘要

2. Prepare acid (+ - 1,4-dihydro-7 - [(3S, 4S) - 3-methoxy-4 - (methylamine) - 1-pyridine-1 - (2-thiazolpidan) - 1,8-naftiridin-3-carboxyl; A pharmaceutical component containing (+ - 1,4-dihydro-7 - [(3S, 4S) - 3-methoxy-4 - (methylamine) - 1-pirolidine is also provided.(l) 4-oxo-1 - (2-tiazolyl) - 1,8-nafeldin-3-carboxyl and the treatment method using these compounds. 1. Characteristic 1: a product for the production of (+ - 1,4-dihydro-7 - [(3S, 4S) - 3-methoxy-4 - (methylamine) - 1-pyridyl-4 -- 4 - (methylamine) - 1-hydroxy-1 - (2-thiazolidine) - 1,8-nafiridin-3-carboxycharacterized in that it comprises: i) opening the epoxide of compound 3 with methylamine to obtain compound 4, ii) resolving compound 4 with a chiral acid selected from L - (-) malic acid and L - (-) - pyroglutamic acid to obtain compound 5A or 5B, iii) protecting the secondary amine of compound 5A or 5B with the tert-butoxycarbonyl protecting group to obtain compound 6, iv) methylating the free hydroxyl group of compound 6 with a methylating agent,v) desproteger los grupos amino con monohidrato de cido p-toluensulf nico para obtener el compuesto 8 y vi) hacer reaccionar el compuesto 8 con el Compuesto 10 para obtener cido (2B) -1 4-dihidro-7- (3S 4S) - iii) protect the secondary amine of compound 5A or 5B with the tert-butoxycarbonyl protecting group to obtain compound 6, iv) methylate the free hydroxyl group of compound 6 with a methylating agent, and v) deprotect the amino groups with acid monohydrate p-toluenesulfonic to obtain compound 8.