3 '- N - Desmethyl - 4' - O - (2 - dietilaminoetanoil) - 6 - methyl - 9A - aza - 9th - homoeritromicina, Crystalline Forms 1, 2 and 3, a process for their preparation, Pharmaceutical composition containing same and their use for the preparation of a Medicament useful for Treatment of inflammatory diseases

摘要

Compound 3 '- n-destil-4' - O - (2-diethylmethylamphetamine) - 6-o-methyl-9a-aza-9a-homeritromicina a, with formula (1). The process of preparation. A pharmacist who understands this I use an effective drug to treat neutron controlled inflammation. 1. Claim 1: compound 3-n-destil-4 '- O - (2-dietelaminoyl) - 6-o-metr-9a-aza-9a-homeritromicina a, characterized by formula (1): or salt. The fifth requirement: a formula in the form of a crystal according to the fourth requirement,It is characterized in that XRPD cathode is represented by 2q angle and obtained by using a two-dimensional spectrometer radiated by copper. XRPD cathode includes 2q (2q /) angle and at least five positions selected from the group, including: 4.6, 5.6, 7.7, 9.6, 10.6, 11.0, 11.6, 11.8, 12.2, 14, The distance of grade D is 19.1, 15.9, 18.9, 18.4, 19.0, 20.5, 21.1 and 22.0 degrees respectively, and the distance of grade D is 19.1, 15.9, 11.5, 9.2, 8.4, 8.0, 7.7, 7.5, 7.2, 6.3, 5.6, 4.8, 4.7, 4.3, 4.2 and 4.0 angles (L) respectively. Item 6: according to Item 4, a formula of crystal formThis is the second form defined by the employer of XRPD with 2q angle, and obtained by a two-dimensional spectrometer with copper radiation. The employer of XRPD includes at least five 2q angles (2q / degree), selected from a group consisting of 9.1, 9.4, 10.4, 10.9, 11.5, 12.0, 13.0, 13.4 and 14.7. 15.4, 15.7, 16.5, 16.8, 18.7, 19.2, 19.5, 19.8 and 20.8 are 9.7, 9.5, 8.5, 8.1, 7.7, 7.4, 6.8, 6.6, 6.6, 6.0, 5.8, 5.6, 5, 4.6, 4.5 and 4.3 corners (troml), respectively. Item 7: according to Item 4, a formula of crystal formThis is the third form defined by the employer of XRPD with 2q angle and obtained by a two-dimensional spectrometer with copper radiation. The employer of XRPD includes 2q angle (2q / -), and there are at least five selected positions in this group, including: 5.5, 7.3, 7.9, 9.1, 9.5, 10.0, 10.5, 11.0, 11.5, 12.0, 12.6, 14.8, 15.5, 15.8, 16.6, 16.9, 18.2, 18.9, and 19.5 degrees, equivalent to 16.0, 12.1, 11.3, 9.7, 9.4, 8.9, 8.4, 8.1, 8.1, 7.7, 7.0, 6, 5.3, 5.2, 4.9, 4.7, and 4.6 corners (semicolons).