Heterocyclic Compounds, i.e., Autotaxin inhibitors useful for the treatment of tumors, preparing process and Medicine containing them.

摘要

The compounds of Formula 1, wherein R1 is H, a, Hal, OR3 (R3), n 2, n = 2 cr3n (R3), SR3, NO2, CN, coor3 (R3), with 2, nr3coa, nr3so2a, so2n (R3), S (o) - [MA C (R3) 2] 2 NN (R3), or C (R3) [2] PN (R3) 2, C (R3) s [2] NN (R3) 2, - NR1 [C (R3) 2] 2 NN (R3), nhcon (R3) 2, (R3 conr3) 2, C (R3) [2] NN (R3) 2 or COA, R3 is H or X is o, NH Or CH2 CH2, and CH2O, or absent.R is as in formula (2), where n = 2 or 3; Formulae (3) where n = 1 or 2, formulas (4); R4 is H, or phenyl, Het is as in formula (5); it is unbranched or branched alkyl C1 - 10, with 1 - 7 h Atoms can be replaced by Oh, F, cl and / or BR, and / or where one or two CH2 groups PU Or be replaced by Eden, NH and / or s, or alkyl cyclic C3 - 7, Hal IS F, CL, Br or I, N is 0, 1,2 or 3, M is 0, 1 or 2, p is 0, 1, 2, 3, 4 or 5, as well as their stereoisomers and pharmaceutically acceptable salts, including mixtures in all proportions. Are i.e., Autotaxin inhibitors and can be used for the treatment of tumors.