Triazole compounds bearing a Substituent of Sulphur and its use in Antifungal Antifungal compositions for the control of Harmful fungi and for the treatment of cancer, Viral Infections and infections with pathogenic fungi.

摘要

Triazole compounds containing sulfur substitutes, agricultural ingredients containing sulfur, compounds used as fungicides and intermediate compounds used in production methods. Item 1: triazole compound, which is characterized by the first and second formulas, wherein: het is a heterocyclic ring composed of 3, 4, 5, 6 or 7 saturated, partially unsaturated or aromatic compounds, including 1, 2 or 3 heteroatoms selected from n, or as members of the ring, wherein the heterocyclic ring can carry 1, 2, R5 alternative R3 or 4; a is a linear C1-5 asphalt bridge, which can be replaced by R7 alternative 1, 2, 3 or 4; and is O, s or N8; R1, R2, R3 and R4,Independent of each other,are selected from hydrogen, halogen, OH, SH, NO2, CN, C1-4 alkyl, C1-4 haloalkyl, C2-4 alkenyl, C2-4 haloalkenyl, C2-4 alkynyl, C2-4 haloalkynyl, C3-8 cycloalkyl, C3-8 halocycloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C1-4 alkenyloxy, C1-4 haloalkyloxy, C1-4 alkynyloxy, C1-4 haloalkyloxy, C3-8 cycloalkoxy, C3-8 halocycloalkoxy, C1-4 alkylthio, C1-4 haloalkylthio, C1-4alkenylthio, C1-4 haloalkylthio, phenyl, C1-4alkyl, phenylC 1-4 alkoxy, phenoxy, phenylthio, where the portion of phenyl in the last 5 radicals mentioned may carry 1 , 2, 3, 4 or 5 substituents R9 saturated heterocyclic ring,3, 4, 5, 6 or 7 members with partial or maximum unsaturation, including 1, 2 or 3 heteroatoms selected from n or s as ring members, wherein heterocyclic ring can carry 1, 2 or 3 R9 substitutes; cor10, cour10, conr15r16, n15r16 and S (or) R10, In this case, the absorption part of the above-mentioned excimer can carry 1, 2 or 3r18 substituting agent, while the circulation part of the former excimer can carry 1, 2 or 3r19 or R1, R2 or R3 and R4 substituting agent, plus the carbon atom connected with it, forming a partially or partially unsaturated carbon ring Maximum unsaturated 5,6 or 7 members or a partially unsaturated or unsaturated or unsaturated heterocyclic ring, which is composed of 5, 6 or 7 members, including 1, 2 or 3 heteroatoms selected from O, s and N as rings; in which, the carbon ring or heterocyclic ring can carry 1, 2 or 3 R9 substitutes; each R5 can independently select halogen, - 4, 1-1-4, 1-1-4, 1-1-4, 1-4, 1-1-4, 1-1-4, 1-4, 1-1-4, C1-4, C1-4, halogen-4,C1-4 alkenylthio, C1-4 haloalkynylthio, phenyl, C1-4 phenyl-C1-4 phenyl-alkoxy, phenoxy, phenylthio, where the portion of phenyl in the last 5 radicals mentioned may carry 1, 2, 3, 4 or 5 R9 substituents a saturated heterocyclic ring, partially unsaturated or with maximum unsaturation of 3, 4, 5, 6 or 7 members containing 1, 2 or 3 heteroatoms selected from N, O and S as ring members, wherein the heterocyclic ring may carry 1, 2 or 3 substituents R9 COR10, COOR10, CONR15R16, NR15R16 and S (O) pR10, where the aliphatic portions in the foregoing radicals may carry 1,2 or 3 R18 displacer, in which the circumferential part of the electrode can carry 1, 2 or 3 R19 displacer; or two R5 radicals are combined in the adjacent ring atoms, and the ring atoms attached to them form a local unsaturated or unsaturated carbon economic circle, with a maximum unsaturation of 5, Six or seven partially unsaturated or unsaturated or unsaturated heterocyclic rings, consisting of five, six or seven members, including one, two or three heteroatoms selected from O, s and N as ring members; in such ring or heterocyclic ring, one, two or three R9 substitutes can be carried; R6 is selected from hydrogen, C1-10 tar, halide. C1-1018. Alquenilo C2-10, haloalquenilo C2-10, c12-10, c12-10, C2-10, cycloquilo c3-10, halocycloquilo c3-10, phenyl, phenyl-c1-4. In these substances, the ratio of phenyl to the last two groups can carry 1, 2, 3, 4 or 5 R11 substitutes and a saturated heterocycle, Partially unsaturated or aromatic, consisting of 5 or 6 members, containing 1, 2 or 3 heteroatoms selected from n or s as members of the ring, in which case the heterocyclic ring may carry 1, 2 or 3 R11 substitutes, or in the case of M = 0, from - C (= O) R12, - C (= s) 2r12, - CN, - P (= q) r13r14, M and a set of third-order equations in which het, a, y, R1, R2,R3 and R4 are defined for Formula 1 and II and are binding points with other molecules; r6a is selected from hydrogen, C1-10 tar, C1-10 halide, alquenilo C2-10, C2-10 calcium halide, c12-10 tar, C2-10, c12-10, c12-10 halogenated tar, c3-10 halogenated cyclopentadiene-10, phenyl, phenyl lo C1-4, which contains phenyl. One, two, three, four or five R11 substitutes, one saturated, partially unsaturated, unsaturated or heterocyclic or aromatic ring with five or six members, including one, two or three heteromorphic atoms selected from n, or s as a ring member, can be carried in such ring, one, two or three R11, (= O) R12 substitutes can be carried,-C (= s) R12, - S (o) 2r12, - CN, - P (= q) r13r14 and m; each R7 is independently selected from halide, oh, SH, n15r16, C1-4 Cypress oil layer, C1-4 halogen-4, alquenio c2-4, haloalquenilo c2-4, Nile c2-4, alcox C1-4, halooxy-4, C1-4, C17 and C14 halide, Under these conditions, the Alic part of the former excimer can carry 1, 2 or 3 R18 substitutes; or two R7 excimers can be combined with two adjacent carbon atoms, and the connected carbon atoms can form a saturated, partially unsaturated or unsaturated or unsaturated 3, 4, 5 carbon thyroid ring, Six to seven members or saturated heterocyclespartially unsaturated or with maximum instability of 3, 4, 5, 6 or 7 members containing 1, 2, or 3 heteroatoms selected from O, S and N as ring members, where the carbocyclic or heterocyclic ring can carry 1, 2 or 3 R9 substituents; R8 is selected from hydrogen, CN, C1-4 alkyl, C1-4 haloalkyl, C2-4 alkenyl, C2-4 haloalkenyl, C2-4 alkynyl, C2-4 haloalkynyl, C1-4 alkoxy, C1-4 haloalkoxy, phenyl, phenyl-C1-4 alkyl, wherein the portion of phenyl in the last 2 radicals mentioned may carry 1, 2, 3, 4 or 5 substituents R9 COR10, COOR10, CONR15R16 and S (O) pR10; each R9 is independently selected from halogen, OH, SH, NR15R16, CN, NO2,C1-4 alkyl, C1-4 haloalkyl, C2-4 alkenyl, C2-4 haloalkenyl, C2-4 alkynyl, C2-4 haloalkynyl, C1-4 alkoxy, C1-4 haloalkoxy, C1-4 alkylthio and C1-4 haloalkyl, wherein the aliphatic portions in the above radicals can carry 1, 2 or 3 R18 substituents; each R10 is independently selected from hydrogen, C1-4 alkyl, C1-4 haloalkyl, C2-4 alkenyl, C2-4 haloalkenyl, C1-4 aminoalkyl, phenyl, phenyl-C1-4 alkyl, wherein the phenyl portion in the last 2 mentioned radicals it can carry 1, 2, 3, 4 or 5 R9 substituents, and a saturated, partially unsaturated or aromatic 5 or 6-membered heterocyclic ring containing 1,2 or 3 heteroatoms selected from N, O and S as ring members, wherein the heterocyclic ring may carry 1, 2 or 3 R9 substituents; each R11 is independently selected from halogen, OH, SH, NR15R16, CN, NO2, C1-4 alkyl, C1-4 haloalkyl, C2-4 alkenyl, C2-4 haloalkenyl, C2-4 alkynyl, C2-4 haloalkynyl, C1-4 alkoxy, C1-4 haloalkoxy, C1-4 alkylthio and C1-4 haloalkylthio, wherein the aliphatic portions in the above radicals may carry 1, 2 or 3 R18 substituents; R12 is selected from hydrogen, C1-10 alkyl, C1-10 haloalkyl, C1-10 alkoxy, C1-10 haloalkoxy, C1-10 aminoalkyl, C3-10 cycloalkyl, C3-10 halocycloalkyl, phenyl, phenyl-C1-4 alkyl,In the case that the phenyl content in the last two roots can carry 1, 2, 3, 4 or 5 R11 substitutes, a heterocyclic ring composed of 5 or 6 saturated, partially unsaturated, unsaturated or aromatic members, which contains 1, 2 or 3 heteromorphisms selected from n or atoms as rings, wherein the heterocyclic ring can carry 1, 2 or 3. Replace R11 and R15 R16, R13 and R14 respectively,are selected from C1-10 alkyl, C1-10 haloalkyl, C2-10 alkenyl, C2-10 haloalkenyl, C2-10 alkynyl, C2-10 haloalkynyl, C3-10 cycloalkyl, C3-10 halocycloalkyl, C1-10 alkoxy, C1 haloalkoxy -10, C1-4 alkoxy C1-10 alkyl, C1-4 alkoxy-C1-10 alkoxy, C1-10 alkylthio, C1-10 haloalkylthio, C2-10 alkenyloxy, C2-10 alkenylthio, C2-10 alkynyloxy, C2 alkynylthio 10, C3-10 cycloalkoxy, C3-10 cycloalkylthio, phenyl, phenylC 1-4 alkyl, phenylthio, phenylC 1-4 alkoxy, and NR15R16 each R15 is independently selected from hydrogen and C1-8 alkyl; each R16 is independently selected from hydrogen, C1-8 alkyl, phenyl, and phenyl-C1-4 alkyl;O R15 and R16 are added together to form a c4-o c5-linear tar bridge or a group - ch2ch2och2ch2-o-ch2ch2n17ch2ch2ch2 -;Each R17 is independently selected from C1-4 hydrogen and hydrocarbon; each R18 is independently selected from nitro; each R18 is independently selected from nitro, CN, oh, SH, cor10, cour10, conr15r16 n15r16, cyclopentyl C3-6, halocyclopentadiene, C3-6, alcox C1-4, halogenated ALCOXY c13-6, cycloxi C3-6, phenyl and phenyl; each R19 is independently selected from nitro, regardless of nitro, oh, oh, Cor10, cor10, conr15 R16, nr15r16, C1-4 tar, C1-4 bittern tar, c13-6, halocycloalkilo C3-6, alcoxi C1-4, halocalcoxi C1-4, cycloxi C3-6, phenyl and phenyl; q is or s; m is equivalent to metal cation or a formula ammonium (nrrd) +,In RA, Rb, RC and RD, independent,From hydrogen, C1-10, phenyl and