The Citrate Salt of 9E - 15 - (pyrrolidin-1-yl 7,12,25 trioxa - ethoxy) - - - 19 - - - tetraciclo 21,24 triaza (18 - 3.1.1 (2.5). Hexacosa (14.18) - 1 (24), 2,4,9,14,16,18 (26), nonaeno 20,24 -

摘要

Certain salts of 9E-15- (2-pyrrolidin-1-iI-ethoxy) -7,12,25-trioxa-19,21,24-triaza-tetracycle [18.3.1.1 (2,5) .1 (14, 18)] hexacosa-1 (24), 2,40,9,14,16,18 (26), 20,22-nonaeno (Compound 1) that have improved properties. In particular, the citrate salt of this compound. Furthermore, pharmaceutical compositions containing the citrate salt and methods of using the citrate salt in the treatment of proliferative disorder. X-ray diffraction shows 2theta peaks at 7.9s + -0.5s; 10.0s + -0.5s; 15.6s + -0.5s; 15.9s + -0.5s; 16.8s + -0.5s; 17.2s + -0.5s, 21.1s + -0.5s; 22.4s + -0.5s.