conserved calcineurin membrane activator (cmac), a therapeutic protein and target

摘要

CALCINEURIN CONSERVED MEMBRANE ACTIVATOR (cMAC), A THERAPEUTIC AND TARGET PROTEIN. The present invention relates to the first known function and biological activity of the hypothetical protein MGC14327, now called cMAC, which is identified here as an important controller of T cell activation. It is contemplated here that cMAC is a suitable drug target for development new therapies to treat cMAC-associated disorders. Therefore, the invention concerns methods for treating said pathological conditions and pharmaceutical compositions. The pharmaceutical compositions comprise modulators with inhibitor or agonist effect on cMAC protein activity and / or cMAC gene expression. The invention also relates to methods for identifying compounds with therapeutic utility for treating said pathological conditions, comprising identifying compounds that can inhibit or agonize cMAC protein activity and / or cMAC gene expression.