compound, method for protecting a mammal against, or treating, a virus, microbial infection, parasite, an autoimmune disease, cancer, allergy or asthma, and, pharmaceutical composition

摘要

COMPOUND, METHOD TO PROTECT A MAMMALIAN INDIVIDUAL AGAINST, OR TREAT, A VIRUS, MICROBIAL INFECTION, PARASITE, AN AUTO-IMMUNE DISEASE, CANCER, ALLERGY OR ASTHMA, AND, PHARMACEUTICAL COMPOSITION It is described that a compound of ~ 1 formula 1 ~ represents a hydrophobic portion adapted to occupy the human CDid C 'channel, R ~ 2 ~ represents a hydrophobic portion adapted to occupy the human CD 1d A' channel, such that R ~ 1 ~ fills at least at least 30% of the volume occupied by channel C 'compared to the volume occupied by nC ~ 14 ~ H ~ 29 ~ terminal of the cx-gaLactosylceramide chain sphingosine when bound to human CD1d and R2 fills at least 30% of the occupied volume of channel A' compared with the volume occupied by the nC ~ 25 ~ H ~ 51 ~ terminal of the 244 acyl chain - galactosylceramide when bound to human CD 1 d R3 represents hydrogen ab or OH, R and R each represent hydrogen, and additionally , when R3 represents hydrogen, R ^ a ^ and R ^ b ^ together , can form a single bond, X represents either -CHA (CHOH) ~ n ~ Y or - P (~ 0) (0) 0CH ~ 2 ~ (CH0H) ~ m ~ Y, where Y represents CHB ~ 1 ~ B ~ 2 ~, n represents an integer from 1 to 4, m represents 0 or 1, A represents hydrogen, one from B ~ 1 ~ and B ~ 2 ~ represents H, OH or phenyl, and the other represents hydrogen or one from B ~ 1 ~ and B ~ 2 ~ represent hydroxy and the other represents phenyl, in addition, when n represents 4, then A together with one of B ~ 1 ~ and B ~ 2 ~ forms, together, a single bond, and the other B ~ 1 ~ and B ~ 2 ~ represents H, OH or OSO ~ 3 ~ H and pharmaceutically acceptable salts thereof; the compounds of formula 1 are indicated for use in the treatment of a virus, microbial infection, parasite, an autoimmune disease, cancer, allergy or asthma.