isolated siren comprising a sense arn filament and a complementary antisense arn filament which together form an arn duplex, a composition comprising at least one siren and use thereof

摘要

siRNA ISOLATED, UNDERSTANDING AN ARN SENSE FILAMENT AND A COMPLEMENTARY ANTI-SENSE ARN FILM TOGETHER TOGETHER WITH AN ARN DUPLEX, COMPOSITION UNDERSTANDING AT LEAST ONE SIGN AND USE OF THE SAME. The present invention relates to novel isolated siRNAs comprising a sense RNA strand and a complementary antisense RNA strand that together form an RNA duplex, characterized in that the sense RNA strand comprises a sequence having at maximum one distinct nucleotide relative to a fragment of 14 to 30 contiguous nucleotides of the exon F nucleotide sequence of the gene encoding myosin Va protein, as well as compositions comprising at least one siRNA and the use of at least that siRNA as a cosmetic agent or therapeutic for depigmentation of the skin.