首页> 外国专利> 12-imidazolyl-1-dodecanol and its pharmaceutically acceptable salts, use thereof in the manufacture of pharmaceutical preparation, and pharmaceutical preparation comprising said compounds and salts

12-imidazolyl-1-dodecanol and its pharmaceutically acceptable salts, use thereof in the manufacture of pharmaceutical preparation, and pharmaceutical preparation comprising said compounds and salts

机译:12-咪唑基-1-十二烷醇及其药学上可接受的盐,其在制备药物制剂中的用途以及包含所述化合物和盐的药物制剂

摘要

B 12-IMIDAZOLIL-1-DODECANOL AND ITS PHARMACEUTICALLY ACCEPTABLE SALES, USE OF THE SAME IN THE PRODUCTION OF PHARMACEUTICAL PREPARATION, AND PHARMACEUTICAL PREPARATION UNDERSTANDING THE COMPOUND AND SAIS D a compound of the present invention refers to a compound of the present invention. to pharmaceutically acceptable salts thereof that can be used for the production of a pharmaceutical preparation, which serves for the prevention or treatment of cancer diseases, pathological consequences of al-coolism, viral hepatitis, steatohepatitis, acute and chronic pancreatitis, diseases toxic kidneys, hepatic insulin resistance in diabetes. mellitus, hepatic lesions in the morbus Wilson and sideroses, ischemic reperfusion injuries, as antidotes against environmental poisons and drug intoxication, to prolong the time that drugs remain in the body or to combat toxic side effects in the administration of chemotherapeutic agents. In the formula, R is a C6- to C40- aliphatic or aromatic hydrocarbon radical, which has a hydrophilic A end and X is at least one electron pair free from a carbon atom or heteroatom and / or a radical which has 227 -electrons.
机译: 12-咪唑-1-十二烷醇及其药学上可接受的销售,在制备药物制剂中使用相同的药物以及理解化合物和SAIS的药物制剂本发明的化合物是指本发明化合物本发明。可用于制备药物制剂的药学上可接受的盐,所述药物制剂用于预防或治疗癌症疾病,酒精中毒,病毒性肝炎,脂肪性肝炎,急性和慢性胰腺炎,中毒性肾脏疾病,肝病的病理后果糖尿病中的胰岛素抵抗。心肌,越橘威尔逊和侧枝玫瑰中的肝损伤,缺血性再灌注损伤,可作为对抗环境毒物和药物中毒的解毒剂,以延长药物在体内的停留时间或对抗化学治疗药物的毒性副作用。式中,R为具有亲水性A末端的碳原子数为6〜40的脂肪族或芳香族烃基,X为至少一个不具有碳原子或杂原子的电子对和/或具有<227>的基团。电子。

著录项

  • 公开/公告号BRPI0710796A2

    专利类型

  • 公开/公告日2011-08-09

    原文格式PDF

  • 申请/专利权人 DIETER MUELLER-ENOCH;THOMAS HAEHNER;

    申请/专利号BR2007PI10796

  • 发明设计人 DIETER MUELLER-ENOCH;THOMAS HAEHNER;

    申请日2007-04-27

  • 分类号A61K31/133;A61K31/164;A61K31/19;A61K31/4164;A61K31/6615;A61P1/16;A61P1/18;A61P3/10;A61P25/32;A61P31/14;A61P35;

  • 国家 BR

  • 入库时间 2022-08-21 18:07:06

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