triabenzo alpha naphtho 2,1,8-cde azulene derivatives, their preparation process and the pharmaceutical compositions containing them

摘要

TRIABENZO DERIVATIVES [ALFA] NAFTO [2, L, 8-CDE] AZULENE, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. The present invention relates to compounds of formula (I), in which: R ~ 1 ~ represents hydrogen, alua (C ~ 1 ~ -C ~ 6 ~) or alkyl hydroxy (C ~ 1 ~ -C ~ 6 ~) , R ~ 2 ~ represents hydrogen, or R ~ 1 ~ and R ~ 2 ~ with the carbon atoms that carry them form a carbon-carbon bond, R ~ 3 ~ represents hydrogen, R ~ 4 ~ represents hydrogen, methyl or alkyl (C ~ 3 ~ -C ~ 6 ~) amino alkyl (C ~ 1 ~ -C ~ 6 ~), hydroxy alkyl (C ~ 1 ~ -C ~ 6 ~), aryl alkyl (C ~ 1 ~ -C ~ 6 ~), heteroalkyl alkyl (C ~ 1 ~ -C ~ 6 ~) or R ~ 3 ~ and R ~ 4 ~ together with the carbon atoms that carry them form a carbon-carbon bond, R ~ 5 ~, R ~ 6 ~, R ~ 7 ~, R ~ 8 ~ represent hydrogen, or two twin substituents (R ~ 5 ~ and R ~ 6 ~, and / or R ~ 7 ~ and R ~ 8 ~) form an oxo, thioxo group or imino, - R ~ 9 ~ represents hydrogen, halogen, alkyl (C ~ 1 ~ -C ~ 6 ~) alkoxy (C ~ 1 ~ -C ~ 6 ~) hydroxy, cyano, nitro, polyhaloalkyl (C ~ 1 ~ -C ~ 6 ~), eventually substituted amino, R ~ 10 ~, R ~ 11 ~ represent hydrogen, halogen, alkyl (C ~ 1 ~ -C ~ 6 ~), alkoxy (C ~ 1 ~ - C ~ 6 ~), hydroxy, cyano, nitro, polyhalo alkyl (C ~ 1 ~ -C ~ 6 ~), amino eventually substituted, n represents an integer between 0 and 4, m represents an integer between 0 and 2, p represents an integer between 0 and 3, X represents a group NR ~ 12 ~, - R ~ 12 ~ represents hydrogen, alkyl (C ~ 1 ~ -C ~ 6 ~), alkenyl (C ~ 2 ~ -C ~ 6 ~) aryl alkyl (C ~ 1 ~ -C ~ 6 ~), polyhaloalkyl (C ~ 1 ~ -C ~) 6 ~), their enantiomers, diastereoisomers, N-oxides, as well as their addition salts to a pharmaceutically acceptable acid or base, medicaments.