methods for modifying release and for controlled release of a transforming growth factor beta protein, use of a fibrin sealant, and kit for preparing a fibrin sealant

摘要

METHODS FOR MODIFYING RELEASE AND FOR CONTROLLED RELEASE OF A TRANSFORMING GROWTH-BETA FACTOR PROTEIN, USE OF A FIBRINE SEALER, AND, KIT TO PREPARE A FIBRINE SEALER. The present invention relates, in general, to a fibrin sealant, which contains growth factor beta (TGF- 225) for controlled in situ release for therapeutic applications, including musculoskeletal disorders, such as bone and cartilage disorders , soft tissue disorders and cardiovascular diseases.