The manufacturing process of an injectable solution with active princu00ecpio based spheres of polymethylmethacrylate (PMMA) and injectable composition with PMMA

摘要

The manufacturing process of an injectable solution with the active ingredient based on spheres of polymethylmethacrylate (Pnma) and injectable composition with PMMA.The present invention relates to a process for the manufacture of an injectable solution with active principle based on polymethylmethacrylate (PMMA) spheres and composiu00e7u00e3oinjetu00e1vel with PMMA to 30%, 10% and 2%.Comprising the steps of: fractionation of raw materials approved for use; sterilization of the raw materials less than truckload non sterile; purification of the spheres of PMMA to homogenize their sizes; transfer of raw materials less than truckload and sterilized under the system of FL Laminar flow to a reatorcom agitation system axial helical conformation control and temp records;Eratura, pressure and stirring rate; transfer of raw materials in proportions suitable for constu00e1ncia of viscosity of a colloidal mixture resulting; maintenance of the resulting blend under constant agitation for 02 06 (two to six) hours; rest and stabilization by The time of 10 (ten) aditional hours; transfer to the colloidal mixture under constant stirring.Of the following raw materials remaining: spheres of polymethylmethacrylate and solution of calcium gluconate, and keeping the mixture under constant agitation for homogenization by the period of 1 - 2 (a aduas) hours.