Molecular markers derived from bombesina radioactive for diagnosis and therapy of tumors superexpressam receptors for peptu00ecdeo releasing gastrina and their application.

摘要

Molecular markers derived from bombesina radioactive for diagnosis and therapy of tumors superexpressam receptors for peptideo releasing gastrina and its applications the present invention refers to a series of radiolabelled compounds for diagnosis and treatment of tumors that And superexpressam receptors for the peptide releasing gastrina, such as tumors of the prostate.Breast and lung, among others, and their metastases. The compounds are analogues of the bombesina, a neuropeptideo derived from anfibio of 14 amino acids, and have been proposed after studies of molecular modeling, by which the original structure of the bombesina was modified in its first five amino acids.The molecular markers resulting from the unprecedented changes have provided good results in studies of radiolabelling and stability in vitro and have the main advantage compared to the fast whitening sangtiu00edneo existing markers, the low accumulation of abdominal and seletivi Dade by tumour cells in vivo.Demonstrated in preclinical studies involving mice animal model of human healthy and tumor.