A human or Humanized Antibody, or a fragment thereof with an Antigen binding region that is specific to direct the Protein to the Receptor of Human thymic stromal limfoproteina (htslpr)

摘要

1. - an isolated portion of an Antibody or Antigen of the same link, which comprises a sequence of the variable region of heavy chain of SEQ ID no: 7 or the SEQ ID no: 21. 2.- isolated an Antibody or a portion of the same Antigen Link, which comprises a sequence of the variable region of heavy chain of SEQ ID no: 7, and a sequence of the variable region of light chain of SEQ ID no: 8, or a sequence of the variable region of heavy chain The SEQ ID no: 21, and a sequence of the variable region of light chain of SEQ ID no: 22. 3.The Antibody of claim 2, which includes cdrh1, H2 and H3 of SEQ ID: 1, 2, and 3, respectively, of SEQ ID Nos: 15, 16, and 17, respectively, or a sequence of cdrl1, L2 and L3 of SEQ ID Nos: 4 5 and 6, respectively, of SEQ ID Nos: 18, 19 and 20, respectively Mind. 4.The Antibody of claim 2, which includes the cdrh1, H2 and H3 of SEQ ID: 1, 2, and 3, respectively, of SEQ ID Nos: 15, 16, and 17, respectively, and a sequence of cdrl1, L2, and L3 of SEQ ID Nos: 4, 5, and 6, respectively, of the SEQ ID no: 18, 19 and 20, respec Ly. 5.The Antibody of claim 2, which comprises an amino acid sequence of the variable region of heavy chain is at least 80 percent identical to SEQ ID no: 7, and an amino acid sequence of the variable region of light chain is at least 80 Ci This is identical to the SEQ ID no: 8Or comprising an amino acid sequence of the variable region of heavy chain is at least 80 percent identical to SEQ ID no: 21, and an amino acid sequence of the variable region of light chain is at least 80 percent identical to SEQ ID no: 22. The Antibody of claim 2, which is a Chimeric Antibody.