A CD37 Antibody derived from a murine monoclonal antibody

摘要

Yhumanizados CD37 Antibody Chimeric and loscontienen Pharmaceutical compositions are useful for the treatment of B Cell malignancies and autoimmune diseases and inflamatoriasque involve B cells in their patologu00eda.1.An Antibody Molecule that binds to cd37humano and DEA) that is derived from a murine monoclonal antibody to Pori) is defined which includes a heavy chain variable Amino Acid Sequence shown in SEQ ID no: 2; ii) a variable light chain comprising a sequence of Minou00e1cidos shown in SEQ ID no: 4Deb) or from a Human Antibody does not recognize the Human mismoepu00edtopo of CD37 Antibody defined in (a) or that recognizes an epitope that is near or with the sesuperpone epitope; in which the Molecule is a anticuerpoquimu00e9rico or humanizado.2. antibody- a claim which the Antibody Molecule is a Chimeric Antibody heavy chain variable defined Pori) comprising an Amino Acid Sequence shown in SEQ ID no: 2; ii) a variable light chain comprising Amino Acid Sequence shown in SEQ ID no: 4, (iii) CAD Enas are heavy and Light Constant humano.3.)- A Antibody of claim 2, in that (i) The Constant heavy chain is a Chain lgg1, ii) The Constant Kappa light chain is a Chain.