Derivatives of 2, 4 - diamino pyrimidine as EPH B4 or EPH A2 Inhibitors useful in the treatment of cancer

摘要

1. - a formula compound (I): A1, A2 or A3 are n, while other compounds are selected independently of CH or N; R1 is hydrogen or a group of tar (C1-4), which can be replaced by one or more alternative groups selected from - or5 (R5 is hydrogen or tar (C1-2),ciano halo o -NR6R7 (en el que R6 y R7 se seleccionan independientemente de hidr geno alquilo (C1-2) o alcanoilo (C1-2) el anillo B es un anillo carboc clico o heteroc clico de 5 6 miembros condensado que est opcionalmente CONR13 N (R13) CO SO2N (R13)N (R13) SO2, C (R13) 2O, C (R13) 2S, C (R13) 2N (R13) and N (R13) C (R13) 2, where R13 is hydrogen or C1-6 alkyl, and R11 is selected from hydrogen, C 1-6 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl, aryl or heterocyclyl, C 1-6 alkyl-C 3-8 cycloalkyl, C 1-6 alkyl-aryl or C 1-6 alkyl -heterocyclyl, any of which may be optionally substituted with one or more groups selected from halogen, trifluoromethyl, cyano, nitro, hydroxy, amino, carboxy, carbamoyl, C1-6 alkoxy, C2-6-alkenyl, C2-6 alkynyl -oxy, C1-6-thio alkyl, C1-6-sulfinyl alkyl, C1-6-sulfonyl alkyl, C1-6-amino alkyl, di- (C1-6 alkyl) amino, C1-6-carbonyl alkoxy, N- C1-6 alkylcarbamoyl,N, N-di- (C1-6 alkyl) carbamoyl, C2-6 alkanoyl, C2-6-oxy alkanoyl, C2-6-amino alkanoyl, N-C1-6-C2-6-amino alkanoyl, C3- alkenyl 6-amino, N-C1-6 alkyl-C3-6-alkenoyl, C3-6-amino alkynyl, N-C1-6 alkyl-C3-6-amino alkynyl, ...