Method for identifying a Protein Streptococcus and immunogenic compositions capable of Inducing an immune response against at least two strains and / or serotypes of Streptococcus

摘要

1.A method to identify a Protein of Streptococcus that is capable of eliciting an immune response against at least two strains and / or serotypes of Streptococcus, the method comprises: a) identify at least part of a secreted Protein.A protein associated with the surface and / or a Protein having at least 50% Sequence identity with a bacterial virulence factor; b) select at least one Protein identified in Step a) is kept on at least two strains of Streptococcus and / or serotypes; and (c) d Determine if at least a Protein selected in STEP (b) or an immunogenic,Derivative, analogue and / or the same Antibody is able to bind specifically and / or immune cell from an animal infected with one Strain of Streptococcus and / or Serotype, and / or an Antibody and Immune cell from an animal infected with a Second Strain of Streptococcus and / or serotip O.2.A method according to claim 1, wherein Said Protein secreted and / or Protein associated with surface is identified by identifying at least a portion of the genome sequence of Streptococcus a Gene that includes a source of a Protein associated with the surface and / or secreted.