Bicyclic Heterocyclic derivatives and Heterocyclic espirobiciclicos linked pyrazolo 1,5-a pyrimidines procedures for their Preparation and Uses Thereof

摘要

1.- A compound of formula A: and pharmaceutically acceptable salts thereof; wherein R1 is a 5-7 membered heterocyclic ring or a heteroaryl ring, said ring comprising 1-3 heteroatoms selected from N, O or S, and said ring being optionally substituted with one to four substituents selected from -J, -NO2, -CN, -N3, -CHO, -CF3, -OCF3, -R7, -OR7, -S (O) mR7, NR7R7, NR7S ( O) mR7, OR9OR7, -OR9NR7R7, -N (R7) R9OR7, -N (R7) R9NR7R7, -NR7C (O) R7, -C (O) R7, -C (O) OR7, -C (O) NR7R7 , -OC (O) R7, -OC (O) OR7, -OC (O) NR7R7, NR7C (O) R7, -NR7C (O) OR7, -NR7C (O) NR7R7, -R8OR7, R8NR7R7, R8S (O ) mR7, R8C (O) R7, R8C (O) OR7, R8C (O) NR7R7, -R8OC (O) R7, -R8OC (O) OR7, -R8OC (O) NR7R7, -R8NR7C (O) R7,-R8NR7C (O) OR7 -R8NR7C (O) NR7R7 -YR8R10 -YR8NR7R7 y -YR10 R2 se selecciona entre un anillo arilo un anillo arilo bic clico de 9-14 miembros 5-7 miembros y un anillo heteroarilo de un anillo heteroarilo bic clico R8C (O) OR7, -R8C (O) NR7R7, -R8OC (O) R7, -R8OC (O) OR7, -R8OC (O) NR7R7, -R8NR7C (O) R7, -R8NR7C (O) OR7, -R8NR7C (O) NR7R7, -OPO (OR7) 2, -YR8R10, -YR8NR7R7 and -YR10; R3, R4 and R5 are each independently selected from carbon-bonded R6, -XW-R6, H, J, -C (O) OR7, -C (O) NR7R7, -NR7C (O) R7, -CN, alkyl of 1-6 carbon atoms, branched alkyl of 1-8 carbon atoms, cycloalkyl ring of 3-10 carbons, ...