Derivatives of N - heterocyclic carbenes imidazo 1,2 - alpha - (2 - piriidina carboxamidas Preparation and its application in Therapeutics

摘要

1. - compound in accordance with formula (I): X represents an aperiodic group, which is replaced by one or more groups independently selected from the following atoms or groups: halogen, propoxy (C1-C6),1. Asphalt (C1-C6),Nrarb, cyanogen, oxide, combined R8, may be that tar and alcoxi groups are selectively replaced by one or more halogen atoms; R1 represents hydrogen atom, halogen atom, alcoxi group (C1-C6),1. Contract group (C2-C6),Amino group or nrarb; there may be tar and alcoxi groups optionally substituted by one or more halogen atoms, one hydroxyl group, amino group or alcoxi group (C1-C6); R2 represents an heterocyclic group, Substituted by one or more groups independently selected from the following atoms or groups: hydroxyl group, pitch (C1-C6),alcox (C1-C6)halogen, cyano, NRaRb, -CO-R5, -CO-NR6R7, -CO-O-R8, - NR9-CO-R10, the (C1-C6) alkyl and (C1-C6) alkoxy groups being optionally substituted with one or various halogen atoms or hydroxy groups, NRaRb, oxide; R3 represents a hydrogen atom, a (C1-C6) alkyl group,An alcoxi (C1-C6) or a halogen atom; R4 represents a hydrogen atom, a tar group (C1-C4),a (C1-C4) alkoxy group or a fluorine atom; R5 represents a hydrogen atom, a phenyl group or a (C1-C6) alkyl group; R6 and R7, identical or different, represent a hydrogen atom or a group (C1-C6) alkyl or form with the 4 to 7 membered ring carbon atom optionally including another heteroatom selected from N, O or S; R8 represents a (C1-C6) alkyl group; R9 and R10 , identical or different, represent a hydrogen atom or a (C1-C6) alkyl group; Ra and Rb represent, independently of each other, a hydrogen atom,1. A group of asphalt (C1-C6) or a 4-7-knot cycle combined with nitrogen atoms, optionally including another heteroatom selected from n to s, in the form of a base or an acid salt additive.