In silico derived chemical compounds for the preparation of pharmaceutical compositions to reduce or inhibit the virus infection by Dengue and other flaviviruses

摘要

Chemical compounds obtained in silico containing two functionally distinct substructures according to the formula [c] - [A] where [A] is defined as an anchor and a Chemical substructure is able to bind to the e Protein of dengue virus; and [c] defined as head, corresp Where a Chemical substructure covalently attached to the substructure []Where such substructure provides or enhances the ability of the Molecules of the present Invention inhibit infection by dengue virus affecting, or Modulating one or more intermolecular interactions involving Protein and for the preparation of pharmaceutical compositions S.