Process for preparing 5-2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl-4,5,6,7-tetrahydrothieno3,2-cpyridin-2-yl acetate hydrochloride (prasugrelu hydrochloride in polymorphous B form

摘要

the solution concerns the way production hydrochloride 5 - (2 - cyclopropyl - 1 - (2-fluorophenyl) - 2-oxoethyl] - 4,5,6,7-tetrahydrothieno [3,2-c] pyridine - 2 - yl acetate formula (prasugrel hydrochloride) in crystalline form b,while prasugrel base formula ii is dissolved or suspended in an organic rozpouu0161tedle and left to react with chlorovodu00edkem rozpuu0161tenu00fdm in an organic rozpouu0161tedle or in water at temperature in the range of -20.degree.c to 75.degree.c and possibly after pridu00e1nu00ed co solvent with crystallises.