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Compositions for triggering an immune response to the paratuberculosis subspecies of mycobacterium
Compositions for triggering an immune response to the paratuberculosis subspecies of mycobacterium
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机译:用于触发对分枝杆菌的副结核亚种的免疫应答的组合物
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摘要
The invention provides compositions and method for stimulating an immunological response against Mycobacterium avium subspecies paratuberculosis (MPT). The compositions comprise at least five recombinant immunogenic components. The immunogenic components can be MPT antigens or DNA polynucleotides encoding MPT antigens, or combinations thereof. MPT antigens used in the invention include MPT 85A, 85B, 85C, 35 kDa, super oxide dismutase (SOD), MptC, MptD and ESAT-6 protein. The method comprises administering the composition to an animal in an amount effective to stimulate an immunological response against MPT bacteria. The method is of benefit to any animal susceptible to MPT infection, but is particularly beneficial for ruminants.
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