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INHIBITORS OF MATRIX METALLOPROTEINASE, PHARMACEUTICAL COMPOSITIONS THEREOF AND USE OF THEM FOR PREVENTING AND TREATING DISEASES WHERE THE ACTIVATION OF MMP IS INVOLVED
INHIBITORS OF MATRIX METALLOPROTEINASE, PHARMACEUTICAL COMPOSITIONS THEREOF AND USE OF THEM FOR PREVENTING AND TREATING DISEASES WHERE THE ACTIVATION OF MMP IS INVOLVED
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机译:涉及MMP活化的基质金属蛋白酶抑制剂,其药物组合物及其在预防和治疗疾病中的用途
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摘要
Compounds of general formula (I), salts or solvates thereof and pharmaceutical compositions containing same: wherein Z is N or CH or the Z(R1) part is replaced with a covalent bond, m and n is 0, 1, 2 or 3; HET is heteroaryl; X is CF3, halogen, CO-heterocyclyl, COOR3 or CONHR3; R1 is H, (CH2)o-aryl, (CH2)p-heteroaryl, (CH2)q-biphenyl; C(O)-R5; S(O)2-R6; R2 is H, aryl, heteroaryl, Y-(CH2)r-aryl, Y-(CH2)s-heteroaryl, where some of the above substituents may be substituted; Y is O or S; with the exclusion of the compound where HET is 1,3-thiazol, X is COOH, R1 is 4-fluorophenyl and R2 is benzyloxy. The invention also relates to the use of a compound of general formula (I), salts or solvates thereof for the use in the prevention or treatment of diseases where the activation of MMPs is involved in the pathomechanism. In this aspect the use of the above excluded compound is also inventive.
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