首页> 外国专利> BENZOTHIAZEPINE AND BENZOTHIADIAZEPINE DERIVATIVES WITH ILEAL BILE ACID TRANSPORT (IBAT) INHIBITORY ACTIVITY FOR THE TREATMENT OF HYPERLIPIDAEMIA, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

BENZOTHIAZEPINE AND BENZOTHIADIAZEPINE DERIVATIVES WITH ILEAL BILE ACID TRANSPORT (IBAT) INHIBITORY ACTIVITY FOR THE TREATMENT OF HYPERLIPIDAEMIA, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

机译：具有苯胆酸转运（IBAT）抑制作用的高脂血症的苯并噻庚因和苯并噻二嗪衍生物，其制备方法和包含它们的药物组合物

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摘要

The present invention relates to compounds of formula (I) wherein RSUPv/SUP, RSUP1/SUP, RSUP2/SUP, RSUPx/SUP, RSUPy/SUP, M, RSUPz/SUP, v, RSUP3/SUP, RSUP4/SUP, RSUP5 /SUPand RSUP6 /SUPare as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described.

机译：本发明涉及式（I）的化合物，其中R ^{v ，R ^{1 ，R ^{2 ，R ^{x ，R ^{y ，M，R ^{z ，v，R ^{3 ，R ^{4 ，R ^{5 和R ^{6 在其中定义;药学上可接受的盐，溶剂化物，这些盐的溶剂化物及其前药，以及它们作为回肠胆汁酸转运（IBAT）抑制剂用于治疗高脂血症的用途。还描述了它们的制造方法和包含它们的药物组合物。}}}}}}}}}}

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公开/公告号HU227623B1

专利类型
公开/公告日2011-09-28

原文格式PDF
申请/专利权人 ASTRAZENECA AB;
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申请/专利号HU20040001196
发明设计人 STARKE INGEMAR;DAHLSTROM MIKAEL ULF JOHAN;BLOMBERG DAVID;ALENFALK SUZANNE;SKJARET TORE;LEMURELL MALIN;
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申请日2002-09-05
分类号C07D285/36;A61K;A61K31/192;A61K31/397;A61K31/40;A61K31/505;A61K31/554;A61K31/695;A61K31/785;A61K38/05;A61K38/06;A61P;A61P3/06;A61P7/02;A61P9;A61P9/04;A61P9/06;A61P9/08;A61P9/10;A61P17/02;A61P31;A61P43;C07D;C07D281/02;C07D281/10;C07D417/12;C07F7/10;C07K;
国家 HU
入库时间 2022-08-21 18:06:27

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