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LIQUID PHARMACEUTICAL FORMULATIONS FOR PROLONGED RELEASE OF INTERLEUKIN(S), PROCESS FOR THEIR PREPARATION AND DERIVED PRODUCT COMPRISING SUBMICRON PARTICLES CONTAINING SUCH FORMULATIONS
LIQUID PHARMACEUTICAL FORMULATIONS FOR PROLONGED RELEASE OF INTERLEUKIN(S), PROCESS FOR THEIR PREPARATION AND DERIVED PRODUCT COMPRISING SUBMICRON PARTICLES CONTAINING SUCH FORMULATIONS
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机译:长时间释放白细胞介素的液体药物配方,其制备过程和包含此类配方的亚微米颗粒衍生产品
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摘要
The invention relates to novel pharmaceutical formulations based on fluids and stable aqueous colloidal suspensions for the sustained release of an interleukin IL- (and one or more other optional active principles), and to the applications, particularly the therapeutic applications, of said formulations. According to the invention, the formulation is a low-viscosity aqueous colloidal suspension of submicronic particles of water-soluble, biodegradable polymer PO bearing hydrophobic groups (GH). The aforementioned particles are noncovalently associated with at least one interleukin (and one or more other optional active principles) and form a gelled deposit on the injection site, said gelling being caused by a protein present in the physiological medium.
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