SUSTAINED DRUG RELEASE COMPOSITION DEMONSTRATING AN ASCENDING ZERO ORDER RELEASE PATTERN AND METHODS OF MANUFACTURING SUCH A COMPOSITION

摘要

Disclosed are dosage forms and methods for sustained release of a drug including : a delay layer comprising a polymeric matrix, and microencapsulated drug, wherein the delay layer is substantially free of non-microencapsulated drug; and a second layer including a polymeric matrix, and non-microencapsulated drug matrix; wherein the second layer is located adjacent to the delay layer.