POLYOXYALKYLENE GLYCOLS OR ESTERIFIED MONOALKYLATED POLYOXYALKYLENE GLYCOLS, FORMULATIONS COMPRISING THEM AND USE THEREOF AS SURFACTANTS AND IN THE PREPARATION OF FORMULATIONS (INCLUDING PHARMACEUTICAL FORMULATIONS)

摘要

New non-ionic surfactants in the form of polyoxyalkylene glycol hydroxy fatty acid derivatives or monoalkylated polyoxyalkylene glycol hydroxy fatty acid derivatives having a polyoxyalkylene / alkyl polyoxyalkylene chain with a chain-length of 25 - 455 repeating units and a specified substituent on the hydroxy position of the specified hydroxy fatty acid, according to the general formula (I) CH3 - (CH2)x - CH - (CH2)y - CO - [-O - R3 - ]z - O - R1 R2 - O (I); wherein for example R1 is methyl, R2 is optionally substituted C14 - C22 acyl, alkyl, or alkenyl, R3 is ethylene, x is 2-12, y is 7-17, (x + y) is 3-19 and z is 25-57; advantageously prepared by involving an enzymatic process, formulations comprising them, their use as solubilizers and a process involving a hydrolytic enzyme for preparing them.