IGF-1R BINDING HUMAN MONOCLONAL ANTIBODY OR ANTIGEN-BINDING PORTION THEREOF, ISOLATED POLYNUCLEOTIDE ENCODING THE SAME, PHARMACEUTICAL COMPOSITION COMPRISING IT AND USE THEREOF IN THE PREPARATION OF MEDICAMENTS FOR TREATING CANCER

摘要

The present invention relates to human antibodies, for example those directed to the human IGF-1 receptor (IGF-1R) that are for treatment of cancer, that have one or more selected mutated residues replaced with germline residues. A replaced residue can be a somatic mutation in a framework region.