N-(5-SUBSTITUTED-2-NITROPHENYL)AMINE DERIVATIVES AND METHODS FOR THE PREPARATION OF 6-SUBSTITUTED-1-METHYL-1-H-BENZIMIDAZOLE DERIVATIVES UTILIZING THE SAME

摘要

Disclosed are novel production intermediates (IIa) and (III) of a 6-substituted-1-methyl-1-H-benzimidazole derivative (I) as a publicly-known pharmaceutically active ingredient. Also disclosed is a production method suitable for mass synthesis of N-(5-substituted-2-nitrophenyl)-N-methylamines (II) as production intermediates. Further disclosed is a method for efficiently producing a 6-substituted-1-methyl-1-H-benzimidazole derivative (I) from a production intermediate (II) through a short process. The present invention relates to a method for producing a compound (I) represented by the formula below and a production intermediate of the compound (I). (III) (I) (In the formula, R2 represents a phenyl group which may have a substituent such as a C1-C6 alkyl group or the like, and X represents an oxygen atom, a sulfur atom or a nitrogen atom.)