首页> 外国专利> N-(5-SUBSTITUTED-2-NITROPHENYL)AMINE DERIVATIVES AND METHODS FOR THE PREPARATION OF 6-SUBSTITUTED-1-METHYL-1-H-BENZIMIDAZOLE DERIVATIVES UTILIZING THE SAME

N-(5-SUBSTITUTED-2-NITROPHENYL)AMINE DERIVATIVES AND METHODS FOR THE PREPARATION OF 6-SUBSTITUTED-1-METHYL-1-H-BENZIMIDAZOLE DERIVATIVES UTILIZING THE SAME

机译:N-(5-取代的-2-硝基苯胺)衍生物和利用其制备6-取代的-1-甲基-1-H-苯并咪唑衍生物的方法

摘要

Disclosed are novel production intermediates (IIa) and (III) of a 6-substituted-1-methyl-1-H-benzimidazole derivative (I) as a publicly-known pharmaceutically active ingredient. Also disclosed is a production method suitable for mass synthesis of N-(5-substituted-2-nitrophenyl)-N-methylamines (II) as production intermediates. Further disclosed is a method for efficiently producing a 6-substituted-1-methyl-1-H-benzimidazole derivative (I) from a production intermediate (II) through a short process. The present invention relates to a method for producing a compound (I) represented by the formula below and a production intermediate of the compound (I). (III) (I) (In the formula, R2 represents a phenyl group which may have a substituent such as a C1-C6 alkyl group or the like, and X represents an oxygen atom, a sulfur atom or a nitrogen atom.)
机译:公开了作为已知的药物活性成分的6-取代的-1-甲基-1-H-苯并咪唑衍生物(I)的新的生产中间体(IIa)和(III)。还公开了适合于大规模合成作为生产中间体的N-(5-取代的-2-硝基苯基)-N-甲胺(II)的生产方法。还公开了通过短过程从生产中间体(II)有效地生产6-取代的-1-甲基-1-H-苯并咪唑衍生物(I)的方法。本发明涉及由下式表示的化合物(I)的制备方法和化合物(I)的制备中间体。 (III)(I)(式中,R 2表示可以具有碳原子数为1〜6的烷基等的取代基的苯基,X表示氧原子,硫原子或氮原子。)

著录项

  • 公开/公告号IL213615A

    专利类型

  • 公开/公告日2011-07-31

    原文格式PDF

  • 申请/专利权人 DAIICHI SANKYO COMPANY LIMITED;

    申请/专利号IL213615

  • 发明设计人

    申请日2011-06-16

  • 分类号C07Dnull/null;

  • 国家 IL

  • 入库时间 2022-08-21 18:06:02

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