AN IMPROVED PROCESS FOR THE PREPARATION N2-ACETYL-9-(1,3-DIACETOXY-2-PROPOXYMETHYL) GUANINE--A USEFUL INTERMEDIATE FOR GANCICLOVIR

摘要

: The present invention relates to a process for the preparation N2-acetyl-9-(1,3-diacetoxy-2-propoxymethyl) guanine which comprises alkylation of diacetyl guanine in the presence of monoacetyl guanine or acetic acid, with 2-acetoxymethoxy-1,3-diacetoxy propane in an inert organic solvent optionally containing a catalyst and N2-acetyl-7-(1,3-diacetoxy-2-propoxymethyl) guanine. The compound, N2-acetyl-9-(1,3-diacetoxy-2-propoxymethyl) guanine, is a important intermediate for preparation of antiviral compound, Ganciclovir. No. of Pages : 14 No. of Claims : 7