A PROCESS FOR THE PREPARATION OF A NOVEL COLLAGEN SCAFFOLD USEFUL FOR WOUND DRESSING

摘要

The process involves purification of collagen from fetal calfskin by conventional method. Development of antibacterial agent loaded alginate microsphere by water/oil emulsion technique through ionic gelation of alginate, thus entrapping antibacterial agent in the alginate polymer matrix followed by rigidization and drying of the drug loaded microspheres. The prepared drug loaded microsphere was impregnated in the prepared collagen and subsequently initiating fibrillation. The drug impregnated fibrillated collagen was cast as a thin scaffold under controlled temperature and aseptic environment. The developed novel collagen scaffold impregnated with antibacterial agent delivers the drug in a controlled manner thus reducing frequency of dressing and makes wound assessment easier.