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RECOMBINANT CHIMER HEPATITIS B CORE (HBC) PROTEIN MOLECULE AND IMMUNOGENIC PARTICLES FORMED BY SAID HBC CHIMER PROTEIN MOLECULE
RECOMBINANT CHIMER HEPATITIS B CORE (HBC) PROTEIN MOLECULE AND IMMUNOGENIC PARTICLES FORMED BY SAID HBC CHIMER PROTEIN MOLECULE
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机译:重组嵌合肝癌B核心(HBC)蛋白分子和所说的HBC嵌合蛋白分子形成的免疫原性颗粒
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摘要
A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid protein (HBc) is disclosed that is engineered for both enhanced stability of self-assembled particles and the display of an immunogenic epitope. The display of the immunogenic epitope is displayed in the immunogenic loop of HBc, whereas the enhanced stability of self-assembled particles is obtained by the presence of at least one heterologous cysteine residue near the carboxy-terminus of the chimer molecule. Methods of making and using the chimers are also disclosed.'
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