AN ASSEMBLY FOR ADHESIVE ATTACHMENT TO THE SKIN OR MUCOSA A STACKED PLURALITY OF COMPONENTS FOR THE MANUFACTURE THEREOF, AND A SYSTEM FOR HANDLING OF

摘要

The invention relates to an assembly for adhesive attachment to the skin or mucosa of a host. Said assembly includes an outer backing layer (112) including an inner surface and an outer surface, a first layer of adhesive (110) disposed on said inner surface of said outer backing layer (112), an inner backing layer (124) including an inner surface and an outer surface, a second layer of adhesive (122) disposed on said inner surface of said inner backing layer (124) for adhesive attachment of said assembly to said skin or mucosa of said host. An intermediate release liner (104) disposed between said first layer of adhesive (110) and said outer surface of said inner backing layer (124), said intermediate release liner (104) including an inner surface and an outer surface is also disclosed. Both said inner surface and said outer surface of said intermediate release liner (104) includes a releasable surface. Said intermediate release liner (104) further includes at least one open area (114), and wherein said first adhesive layer includes a portion adhesively bonded to and in direct contact with said outer surface of said liner backing layer at said at least one open area and the remaining portion of said first adhesive layer temporarily covered by said intermediate release liner (104). The invention provides transdermal patch systems for use in the application of active agents to a patient or host.