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A novel dry stick device construction and method for determining an analyte in a sample using said dry stick device
A novel dry stick device construction and method for determining an analyte in a sample using said dry stick device
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机译:一种新颖的干棒装置构造和使用所述干棒装置测定样品中分析物的方法
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摘要
Disclosed is a dry stick device for the determination of an analyte in a sample, said device comprises: (i) optionally a solid support, (ii) at least one reagent pad comprising a reagent or a combination of reagents capable of reacting with the analyte, a derivative of said analyte or an indicator compound for said analyte to provide a detectable signal when in a moistened state, the at least one reagent pad providing a first environment for said reagent(s), said first environment permitting an improved storage stability of the reagent(s) and dry stick device when in a non-moistened state, (iii) a regulating pad being in contact with the at least one reagent pad, the regulating pad creating a second environment for said reagent(s) when in a moistened state, said second environment permitting an increased rate of reaction between the analyte and the reagent(s), and wherein the sample is applied to one surface of the dry stick device and the detectable signal is detected on the same surface and wherein the determination of the analyte is based on an enzyme-based determination and wherein the condition in the first environment is provided by adjusting the pH-value to a value that deviates from the optimal pH-value of the enzyme(s) and wherein the condition in the second environment is provided by regulating the pH-value to a value that approaches the optimal pH-value of the enzyme(s) and wherein the different environments have different pH-values. Also disclosed is the method of making the disclosed dry stick device and the use of the dry stick device in determining an analyte in a sample.
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