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PARENTERAL FORMULATION COMPRISING PROTON PUMP INHIBITOR STERILIZED IN ITS FINAL CONTAINER BY IONIZING RADIATION
PARENTERAL FORMULATION COMPRISING PROTON PUMP INHIBITOR STERILIZED IN ITS FINAL CONTAINER BY IONIZING RADIATION
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机译:包含通过电离辐射在其最终容器中灭菌的质子泵抑制剂的腹腔配方
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摘要
Disclosed is a stable sterilized parenteral formulation comprising a solid formulation comprising an acid susceptible proton pump inhibitor and optionally pharmaceutically acceptable excipients wherein said formulation has been sterilized in its final container by ionizing radiation, and the proton pump inhibitor is selected from a thioester of Formula (I) wherein Het 1 is a pyridine or aryl amine, Het2 is a benzimidazole the further substituents are defined as in the specification. Also disclosed is a process to prepare said formulation and the use of said formulation for the manufacture of a medicament for the treatment of gastrointestinal diseases.
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