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PHARMACEUTICAL FORMULATION IN MIXED MICELLAR FORM AND DISPENSER FOR ORAL DELIVERY OF AGENTS AS A SPRAY
PHARMACEUTICAL FORMULATION IN MIXED MICELLAR FORM AND DISPENSER FOR ORAL DELIVERY OF AGENTS AS A SPRAY
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机译:混合胶束形式的药物配方和喷雾剂的口服给药分配器
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摘要
A pharmaceutical formulation delivered as a spray from a metered dose dispenser into the oral cavity for absorption through oral mucosa, comprising an effective amount of (a) a pharmaceutical agent in mixed micellar form, (b) a micelle- forming compound that is an alkali metal alkyl sulfate or a polyoxyethylene sorbitan monooleate, (c) a block copolymer of polyoxyethylene and polyoxypropylene, (d) at least one additional micelle¬forming compound, and ( e) a suitable solven. The invention also provides a dispenser containing the present formulation, and a method of administering this formulation comprising insulin as the pharmaceutical agent, where a dose of the formulation is split to be administered before and after each meal.
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