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Preparation of {4,6-diamino-2 - 1 - (2-fluorobenzene) - 1h-pirazolo 3,4-b piridin-3-il pirimidin-5-il} carbamato de methyl and its purity as active drug source
Preparation of {4,6-diamino-2 - 1 - (2-fluorobenzene) - 1h-pirazolo 3,4-b piridin-3-il pirimidin-5-il} carbamato de methyl and its purity as active drug source
The present Invention relates to a process for the preparation of {4,6-diamino-2 - [1 - (2-fluorobenzyl) - 1H pyrazolo [3,4-b] pyridin-3-yl] pyrimidin-5-yl) methyl carbamate, i.e. of the compound of formula (i) as well as a procedure for purification of the crude product of formula (I ) for use as pharmaceutically active substance for purification, Isolation generates {4,6 - diamino - 2 - [1 - (2-fluorobenzyl) - 1H pyrazolo [3,4-b] pyridin-3-yl] pyrimidin-5-yl} - sulfinildimetano Methyl carbamate (1: 2) of formula (ii) or as an intermediate is generated as an intermediate in this purification procedure as with the case in a mixture.
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