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PROCESS FOR THE PREPARATION OF AN ISOTONIC AQUEOUS ROPIVACAIN INJECTION
PROCESS FOR THE PREPARATION OF AN ISOTONIC AQUEOUS ROPIVACAIN INJECTION
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机译:等渗水性罗帕坦注射液的制备方法
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摘要
The preparation of an injectable solution of ropivacaine by dissolving ropivacaine base in aqueous acidic solution having a molar ratio of acid to ropivacaine base greater than 1:1 eliminates the need for a hydrochloride or hydrochloride monohydrate intermediate in the manufacture of the injectable. The osmolality can be adjusted as needed. The excess acid is neutralized with a base.
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