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G PROTEIN-COUPLED RECEPTOR HIGHLY EXPRESSED IN PROSTATE CANCER AND ITS USES

机译：前列腺癌中高表达的G蛋白偶联受体及其用途

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摘要

A novel gene (designated PHOR-1) that is highly over-expressed in prostate and other cancers and its encoded protein are described. PHOR-1 is a G protein-coupled receptor with homology to receptors involved in olfaction. PHOR-1 in normal human tissues is restricted to prostate, and this gene is highly over-expressed in prostate cancer as well as in cancers of the kidney, uterus, cervix, stomach and rectum. Consequently, PHOR-1 provides a diagnostic and/or therapeutic target for prostate cancer.

机译：描述了在前列腺癌和其他癌症中高度过表达的新基因（称为PHOR-1）及其编码的蛋白质。 PHOR-1是一种G蛋白偶联受体，与涉及嗅觉的受体同源。正常人组织中的PHOR-1仅限于前列腺，并且该基因在前列腺癌以及肾脏，子宫，子宫颈，胃和直肠癌中高度过表达。因此，PHOR-1为前列腺癌提供了诊断和/或治疗靶标。

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公开/公告号AT524549T

专利类型
公开/公告日2011-09-15

原文格式PDF
申请/专利权人 AGENSYS INC.;
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申请/专利号AT20080165936T
发明设计人 RAITANO ARTHUR B.;AFAR DANIEL E. H.;JAKOBOVITS AYA;FARIS MARY;HUBERT RENE S.;MITCHELL STEVE C.;SAFFRAN DOUGLAS C.;
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申请日2000-10-05
分类号A01K67/027;C12N15/12;A61K31/7088;A61K31/713;A61K35/76;A61K38;A61K38/17;A61K39;A61K39/395;A61K48;A61P13/08;C07K14/47;C07K14/705;C07K16/18;C07K16/28;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N5/12;C12N15/09;C12P21/02;C12P21/08;C12Q1/02;C12Q1/68;G01N33/50;G01N33/53;G01N33/566;G01N33/577;
国家 AT
入库时间 2022-08-21 18:03:06

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