Procedure magnetic resonance investigation of a sample using an agent forming magnetic resonance imaging nuclear spin polarized.

摘要

A method of magnetic resonance investigation of a sample, preferably the body of a human or non-human animal, said method comprising i) obtaining an agent imaging MRI including molecules of a compound containing a core nuclear non-zero spin detection and storage of different gyromagnetic ratio values ​​wherein said storage nuclei and detection are separated by 2 to 5 chemical bonds; ii) polarize nuclear spin polarization by said storage nuclei in said imaging agent RM; iii) administering the imaging agent polarized MR to said sample; iv) subjecting said sample to a pulse sequence which causes polarization to be transferred from said storage nuclei to said nuclear spin nuclei nonzero detection, wherein the gyromagnetic ratio of said detection nuclei is greater than that of said storage nuclei ; v) exposing said sample to a radiation at a frequency selected to excite nuclear spin transitions in said detection nuclei; vi) detecting magnetic resonance signals from said sample; and vii) optionally generating an image, dynamic flow data, diffusion data, perfusion data, physiological data or metabolic from said detected data signals.