Stearoyl coa desaturase to identify therapeutic agents that lower triglycerides.

摘要

A method for identifying a modulating agent of stearoyl-CoA desaturase (SCD1), comprising: a) contacting under physiological conditions a chemical agent and a fraction of microsomal membrane having SCD1 activity or such chemical agent and a cell having SCD1 activity; b) detecting a change in said SCD1 activity due to said contacting; c) assaying said chemical agent to further select compounds which do not inhibit in a human biological activity of delta-5 desaturase or delta-6 desaturase, thereby identifying a modulating agent SCD1.