ACID DERIVATIVES 2- (8,9-DIOXO-2,6-DIAZABICICLO (5.2.0) NON-1 (7) EN-2-IL) ALQUILFOSFÓNICO AND ITS USE AS ANTAGONISTS OF THE N-METHYL-D-ASPARTATE RECEIVER (NMDA)

摘要

A compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein: R1 is hydrogen, a C1 to C6 alkyl group, a C2 to C7 acyl group, a C1 to C6 alkanesulfonyl group, or a C6 to aroyl group C14; A is alkylene of 1 to 4 carbon atoms or alkenylene of 2 to 4 carbon atoms; R2 and R3 are independently selected from hydrogen, or with the proviso that at least one of R2 and R3 is not hydrogen; R4 and R5 are independently selected from hydrogen, a C1 to C4 alkyl group, a C5 to C7 aryl group, a C6 to C15 alkylaryl group having 5 to 7 carbon atoms in the aryl ring, a C2 to C7 alkenyl group, or C2 to C7 alkynyl group, or R4 and R5 can together form a C3 to C8 spirocarbocyclic ring; R6 is a C1 to C12 linear or branched alkyl group, a C2 to C7 linear or branched alkenyl or alkynyl group, a C5 to C13 aryl group, a C6 to C21 alkylaryl group having 5 to 13 carbon atoms in the aryl moiety ; a 5 to 13 membered heteroaryl group, a 6 to 21 membered alkylheteroaryl group having 5 to 13 members in the heteroaryl moiety, a C4 to C8 cycloalkyl group, a C5 to C16 alkylcycloalkyl group having 4 to 8 atoms of carbon in the cycloalkyl ring; R7 and R8 are independently selected from hydrogen, a linear or branched C1 to C12 alkyl group, a C2 to C7 linear or branched alkenyl or alkynyl group, a C5 to C13 aryl group, a C6 to C21 alkylaryl group having 5 to 13 carbon atoms in the aryl moiety, a 5-13 membered heteroaryl group, a 6 to 21 membered alkylheteroaryl group having 5 to 13 members in the heteroaryl moiety, or R7 and R8 can together form a cycloalkyl or heterocycloalkyl group that it has 4 to 8 carbon atoms in the ring and optionally one or two atoms selected from nitrogen, oxygen or sulfur; wherein any group R1 to R8 having an aryl, heteroaryl, cycloalkyl or heterocycloalkyl moiety may optionally be substituted on the aryl, heteroaryl, cycloalkyl or heterocycloalkyl moiety with 1 to about 5 substituents independently selected from a halogen atom, a cyano group , nitro or hydroxyl, a C1-C6 alkyl group, or a C1-C6 alkoxy group.