Inhibitors caspase 3, 8, 9 or 10 in combination with MEK inhibitors for the treatment of influenza.

摘要

Combination preparation for use for the treatment of a viral disease caused by influenza viruses, containing at least one active substance selected from the group consisting of inhibitors of caspase 3, namely Z-DEVD-FMK, Ac-DEVD-CHO , Ac-DMQD- CHO, ZD (OMe) e (OMe) VD (OMe) -FMK, ZD (OMe) QMD (OMe) -FMK, and inhibitors of cellular caspases which can activate caspase 3, namely inhibitors caspase 8 Z- LE (OMe) TD (OMe) -FMK, Ac-ESMD-CHO, Ac-IETD-CHO, Z-IETD-FMK, the caspase 9 inhibitors Z-LE (OMe) HD (OMe) -FMK , Z-LEHD-FMK, Ac-LEHD-CHO, and the caspase inhibitors 10 Ac-AEVD-CHO, Z-AEVD-FMK, which inhibits a cellular caspase such that a virus multiplication, characterized in that it additionally contained inhibited at least one substance of antiviral action, selected from the group consisting of MEK inhibitors 2- (2-amino-3-methoxyphenyl) -4-oxo- 4H- (1) benzopyran, U0126, PD18453, PD98059.