N-sulfamoyl-n-benzopiranpiperidinas as carbonic anhydrase inhibitors.

摘要

A compound of Formula I ** (See formula) ** in which: R1 and R2 are independently selected from the group consisting of: hydrogen, C1 to C4 alkyl, C4 to C7 cycloalkyl; or R1 and R2 together form a 5- or 6-membered ring which may optionally contain 1 to 2 heteroatoms independently selected from the group consisting of nitrogen and / or oxygen and which also may be substituted by optionally substituted aryl, heteroaryl or arylenehalogenalkyl optionally substituted; R3 to R6 are independently selected from the group consisting of: hydrogen; halogen; C1 to C4 alkyl; C2 to C4 alkenyl, optionally substituted with aryl; C1 to C4 alkoxy; C1 to C4 alkoxy substituted with halogen provided that the alpha-carbon atom is substituted by other halogen than fluorine if any; C2 to C4; NSO2alquilo C1 to C4; NH2; NO2; C1 to C4 aminoalkyl; C2 to C8 aminodialkyl; cyano; I oxyaryl; I oxyalkylenearyl; I oxiarilenoalquilo; oxialquilenoarilenoalcoxi; C2 to C8 ester; C1 to C8 amido; oxialquilenocarbonilalquilo C2 to C8; oxialquilenoxialquilo C2 to C8; amidoxialquilo C1 to C4; aryl, optionally substituted; heteroaryl, optionally substituted; condensed aryl, optionally substituted; heteroaryl fused, optionally substituted; or R3 and R6 have the same meaning as above and wherein R4 and R5 together form a 5- or 6-membered ring which may optionally contain 1 to 3 heteroatoms independently selected from the group consisting of nitrogen, oxygen and sulfur and you may optionally bear 1 or 2 double bonds and may also contain a carbonyl group and which also may be substituted by C1 to C4 haloalkyl C1 to C4, optionally substituted aryl and / or heteroaryl optionally substituted; or R5 and R6 have the same meaning as above and wherein R3 and R4 together form a 5- or 6-membered ring which may optionally contain 1 to 3 heteroatoms independently selected from the group consisting of nitrogen, oxygen and sulfur and you may optionally bear 1 or 2 double bonds and may also contain a carbonyl group and which also may be substituted by C1 to C4 haloalkyl C1 to C4, optionally substituted aryl and / or heteroaryl optionally substituted; or R3 and R4 have the same meaning as above and wherein R5 and R6 together form a 5- or 6-membered ring which may optionally contain 1 to 3 heteroatoms independently selected from the group consisting of nitrogen, oxygen and sulfur and you may optionally bear 1 or 2 double bonds and may also contain a carbonyl group and which also may be substituted by C1 to C4 haloalkyl C1 to C4, optionally substituted aryl and / or heteroaryl optionally substituted; YX is selected from the group consisting of: HC = CH, CH2-CH2, O = C-CH2, and (HO) (H) C-CH2; and its acid addition salt of physiologically acceptable.