Chimeric for use in cancer treatment adenoviruses.

摘要

A recombinant chimeric adenovirus having a genome comprising an E2B region that, wherein said E2B region comprises a nucleic acid sequence derived from a first adenoviral serotype and a nucleic acid sequence derived from a second adenoviral serotype; wherein said first and second adenovirus serotypes are each adenoviral subgroups B, C, D, E, or F and are selected different from one another; and wherein said chimeric adenovirus is oncolytic and demonstrates an improved therapeutic index a tumor cell.