A method for detecting stable CD25 + CD4 + stable T lymphocytes positive for FoxP3 of a mammal in a sample obtained from said mammal, which comprises analyzing the methylation status of at least one CpG position in the 5 'region upstream of the start of transcription , the 5 'untranslated region, promoter region, introns and / or exon / intron boundaries of the foxp3 gene or an orthologous or paralogic gene thereof, in which hypomethylation is indicative of a stable positive CD25 + CD4 + regulatory T lymphocyte for FoxP3.
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