NEW MUTATIONAL PROFILES IN HIV-1 REVERSE TRANSCRIPTASE CORRELATED WITH PHENOTYPIC DRUG RESISTANCE

摘要

The invention provides novel mutations, mutation combinations or mutationalprofiles of HIV-1 reverse transcriptase and/or protease genes correlated withphenotypic resistance to HIV drugs. More particularly, the present inventionrelates to the use of genotypic characterization of a target population of HIVand the subsequent correlation of this information to phenotypicinterpretation in order to correlate virus mutational profiles with drugresistance. The invention also relates to methods of utilizing the mutationalprofiles of the invention in databases, drug development, ii.e./i, drugdesign, and drug modification, therapy and treatment design, clinicalmanagement and diagnostic analysis.