INHIBITION OF ANGIOGENESIS AND DESTRUCTION OF ANGIOGENIC VESSELS WITH EXTRACTS OF NONI JUICE (MORINDA CITRIFOLIA)

摘要

Noni juice and a protein-free, alcohol precipitate of Noni juice inhibitedangiogenesis in in vitro human angiogenesis models. When growth mediumcontained Noni juice at least over the range from about 2.5% to about 33% (byvolume), angiogenesis was blocked. Moreover, Noni juice and an ethanolprecipitate were able to destroy a pre-existing angiogenic response as well asprevent the development of new vessels. Noni juice was effective in inhibitingthe growth of angiogenic vessels from breast cancer explants. It will also beeffective in treating cancers and non-cancerous diseases whose responseincludes an increase in angiogenesis, e.g., retinopathy of prematurity,neovascular glaucoma, diabetic retinopathy, and psoriasis. The primaryantiangiogenic component is believed to be a carbohydrate with a molecularweight less than about 6000 Daltons. In an initial experiment, oraladministration of Noni juice appeared to adversely affect the antioangiogeniccomponent(s) in the juice.