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SELF-EMULSIFYING FORMULATIONS OF FENOFIBRATE AND/OR FENOFIBRATE DERIVATIVES WITH IMPROVED ORAL BIOAVAILABILITY AND/OR REDUCED FOOD EFFECT
SELF-EMULSIFYING FORMULATIONS OF FENOFIBRATE AND/OR FENOFIBRATE DERIVATIVES WITH IMPROVED ORAL BIOAVAILABILITY AND/OR REDUCED FOOD EFFECT
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机译:具有改善的口服生物利用度和/或降低的食品功效的铁蛋白和/或铁蛋白衍生物的自乳化配方
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摘要
A fibrate self-emulsifying oral formulation with improved bioavailability whencompared to commercially available formulations containing a therapeuticallyeffective dose of fenofibrate, derivative of fenofibrate or mixtures thereofdissolved in a fibrate solubilizer selected from N-alkyl derivative of 2-pyrrolidone, mono- or di- or polyethylene glycol monoethers, C8-12 fatty acidmono- or di-esters of propylene glycol, or combinations thereof, one or moresurfactants and optionally one or more stabilizers useful in the treatment ofhypercholesterolaemia or hypertriglyceridaemia in mammals in the fed or fastedstate.
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